Charles married Lady Georgiana Spencer, Duchess of Devonshire. Georgiana (daughter of John Spencer, 1st. Earl Spencer and Margaret Georgiana Poyntz) was born on 7 Jun 1757 in Althorp Manor, Brington, Northamptonshire, England; died on 30 Mar 1806 in Devonshire House, Piccadilly, Middlesex, England; was buried on 9 Apr 1806 in Derby Cathedral, Derbyshire, England. [Group Sheet]

1. Eliza Courtney was born on 20 Feb 1791; died in 1859; was buried on 7 May 1859 in All Souls', Kensal Green, Middlesex, England.

Charles married Mary Elizabeth Ponsonby on 17 Nov 1794 in St. George's, Hanover Sq. Middlesex, England. Mary (daughter of William Brabazon Ponsonby, 1st. Baron Ponsonby of Imokilly and Hon. Louisa Molesworth) was born on 3 Mar 1775; died on 26 Nov 1861 in St. George's, Hanover Sq. Middlesex, England; was buried in St. Michael & All Angels, Alnwick, Northumberland, England. [Group Sheet]

1. Elizabeth Grey was born on 10 Jul 1798; died on 8 Nov 1880 in St. George's, Hanover Sq. Middlesex, England.
2. Rev. Hon. Sir Francis Richard Grey was born on 31 Mar 1813; was christened on 13 Mar 1814 in Howick, Northumberland, England; died on 22 Mar 1890 in Morpeth, Northumberland, England; was buried in St. Mary the Virgin, Morpeth, Northumberland, England.
3. General Charles Grey was born on 15 Mar 1804 in Howick, Northumberland, England; was christened on 23 Apr 1804 in Howick, Northumberland, England; died on 31 Mar 1870 in St. James's Palace, Westminster, Middlesex, England; was buried in St. Michael & All Angels, Alnwick, Northumberland, England.

Charles married Elizabeth Grey in 1762. Elizabeth was born in 1744; died on 26 May 1822; was buried in St. Michael & All Angels, Alnwick, Northumberland, England. [Group Sheet]